Initially conceived as an aeronautical cannon, the weapon project began in 1928. However, the Italian authorities showed no interest in a calibre heavier than 12.7 mm for aeronautical use. Despite its advanced design, the gun was ahead of its time, as bombers of the time no longer used heavy guns for direct ground fire.

In 1932, Scotti sold the weapon's patent to Swiss Oerlikon, which later resold it to China and some South American countries. However, the weapon was not well evaluated by the Italian authorities, who preferred other models such as the Breda 20/65 Mod. 1935.

Despite its limited initial success, development of the weapon continued under the guidance of Isotta Fraschini, which had acquired the designs in 1938. The Mod. 1939 version was developed and used by the Regia Aeronautica and Regia Marina. During World War II, the weapon was ordered by the Dutch Army and also used by the Wehrmacht against Yugoslav partisans.

After the armistice, the weapon remained in service with the Italian Army and Navy after the war. Further versions were developed, some of which were metal belt-fed. However, due to changes in operational requirements and aircraft technical characteristics, the weapon did not find significant aeronautical use.